Products – DIACORDON®

ELISA

Laboratory test for the early detection of myocardial infarction/ACS

The Diacordon® ELISA [DC-E2] is an immunoassay for the early and specific diagnosis of acute coronary syndrome (ACS).
The ELISA is a quantitative detection method for the enzyme glycogen phosphorylase isoenzyme BB (GPBB). This heart-specific early marker indicates myocardial ischemia.
The Diacordon® ELISA enables the quantitative detection of the enzyme GPBB, which is released into the bloodstream by ischemic heart muscle cells. Elevated GPBB concentrations can be detected in the blood of ACS patients just 30 minutes after the ischemic event.
Sandwich ELISA, 96-well microtiter plates, compatible with commercially available ELISA readers.

Planned in the near future.

The ISO-certified production partner for the Dianeonatal® ELISA System is Mabtech, Sweden.

DIACORDON® ELISA

Know your heart

The enzyme GPBB enters the bloodstream when myocardial ischemia, i.e. an insufficient supply of oxygen to the heart, occurs. Such ischemia leads in the long term to necrosis (cell death) of the affected cells and/or ultimately to infarction. The detection of GPBB in the blood therefore provides information about the course of coronary syndrome (including unstable angina pectoris) and heart attacks. It thus makes a decisive contribution to the diagnosis of heart attack patients.

Pre-existing heart markers, such as Myoglobin and Troponin T, which contribute to the diagnosis of myocardial infarction and are routinely tested, have significant disadvantages: Myoglobin is not heart-specific, it can also be measured after damage to the skeletal muscles or in acute kidney failure and is therefore not clear. Troponin, on the other hand, is heart-specific but can only be detected in the blood three to six hours after the first symptoms. Since troponin is a necrosis marker, irreparable damage to the heart has already occurred at this point.

GPBB is both heart-specific and detectable at an early stage, namely within the first hour. Especially in the case of acute coronary syndrome, this is a decisive advantage, as a quick and accurate diagnosis can save lives.

Cardiology

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